My experience with Cimzia.....

Continuing on the series from my previous experience, which was a negative one with Enbrel.

When I went back to my rheumatologist on March 2nd to review my progress with 25mg Enbrel with 10mg MTX, it was decided I would try Cimzia. Now, I had not heard about Cimzia, and thought the next step would be Stelara. I was to start the following Monday, March 9th. At this stage I was already after two weeks of light treatment in order to relieve my skin of the damage Enbrel had done.

Cimzia consists of two 200mg prefilled syringes (400mg in total) to be injected into each thigh, on the same day as each other. This was the starting dose, And I was still on MTX to help make the injection more effective. As it is such a high dosage, it is to be done every two weeks, 400mg for the first 6 weeks and then 1 thereafter.

 

 (Cimzia starter pack - 2 x 200mg prefilled syringes)

A week and a half after the initial injections, I started to notice pink dots around the injection sites on both thighs. The following day, they appeared as large, red, raised patches and felt hot and itchy. Concerned, I talked to my nurse at light treatment the following day and she reduced the UVB due to the reaction and said to ask my doctor about skipping the next session. This was a Friday morning and unfortunately meant it was proving quite difficult to get my rheumatologist on the phone and I gave up when I didn't get a call back. To my surprise, Saturday morning, I get a call from my rheum to see how I was doing. He heard my concerns and advised me to cancel Monday's session to let the reaction fade, and to not take Cimzia any further.

I continued with my light treatment and revisited my rheum where we decided to give my system a break before starting any different, and to think about starting Stelara in a months time as my next option, which is the next and final topic of this series to discuss.

Have you any experience with Cimzia or any biologics mentioned above?

Until next time....

Sarah x

Review: Bioderma

Firstly, I apologise for the lack of posts, life has been a bit busy/ stressful. Unfortunately this has also resulted in my psoriasis flaring up a bit.. But back to blogging....So you may have seen my recent Bioderma haul, well I feel like I've finally had a chance to put them through their paces and to be honest, none have failed to impress me...

(Bioderma BB Cream)

When I first tried out the Bioderma BB Cream, I wasn't too happy after spending the money on it. I applied it with a foundation brush, and it just seem to cake on my cheeks. I had given up on it but decided to give it another try, this time using my Blank Canvas blending sponge. It applied like a dream, covered my redness which tends to be around my nose and cheek areas, it really gave a flawless, even coverage to my skin. I didn't feel the need to set it with powder.

                                           (Before)                                             (After)

As you can see from the above photos, I am a bit tanned on my face but suffer from quite a bit of redness. The photo on the right is using the BB Cream, which as I previously said, really evens out my skintone and hides all the redness on my face. I'm looking forward to using it further and testing its lasting power. It does only come in one shade 'Light' which can be too dark for paler complexions.

The Bioderma miceller water has been leaving my skin so soft, especially when it comes to removing makeup using the product. Due to work I tend to be outside most of the day and exposed to all kinds of weather (which unfortunetly has been mostly rain lately!) as well as sea air so I like to try and use this to cleanse my fair from any harsh condition my skin endures. I hope to invest in a bigger bottle once I'm done with the smaller option, well worth a try!

Until next time.....

Sarah x

My experience with Enbrel....

It is that time again, another installment. If you have missed my previous posts, I have gone into detail about my experience with topical ointments, tonsilectomy, methotrexate and phototheraphy. Today I talk about my most negative experience to date, which happened at the start of 2015...

In my other post regarding Methotrexate, I ended up feeling very ill while taking a higher dosage in December 2014, while also developing psoriatic arthritis in my elbow earlier that year also. At this time, I also found my skin to be bumpy around the back of my thighs leading me to think maybe my Psoriasis was becoming active again but it wasn't happening at a rapid rate, thankfully. I was always given the options of changing to biologics, but was put off at the thought of having to inject myself. To reference Psoriasis.org, Biologics :- "target specific parts of the immune system. The biologics used to treat psoriatic disease block the action of a specific type of immune cell called a T cell, or block proteins in the immune system, such as tumor necrosis factor-alpha (TNF-alpha), interleukin 17-A, or interleukins 12 and 23. These cells and proteins all play a major role in developing psoriasis and psoriatic arthritis."

Enbrel (etanercept) was prescribed to me in January 2015. With Enbrel, you have a nurse assigned to you who comes to your house and helps to teach you how to inject it yourself. Thursday January 8th was going to be the start date and I was to try 50mg, which comes in pen form (myclic pen pictured above). The injection areas to choose from are either the thighs or stomach, I found the thighs to be the area of choice, alternating between left and right each week. To use the pen, the cap is taken off, and the pen is place on the top of the thigh, pushing down so the guard is pushed back and once you're ready the button is pushed releasing the needle. The first time I did it, I did it wrong as the nurse had confused me saying to count to 10, but I was supposed to wait for the second click (which they say is 10 seconds, sounding that it is been dispensed). Due to my mistake, I didn't get a full dose, but I'd know better for next time, being a weeks time. 

Thursday January 15th, My nurse was unable to attend my home. I remember it the weather had been quite bad around that time, including snowfall in higher areas. I managed to inject myself, after about a half hour of building myself up, it was a case of "F**k it! *click*". I did find the pen to be painful. The nurse had asked if I would prefer to use a syringe which I felt sick at the thought of, but she made a good point that with the syringe you have more control. Once you click the button on the pen, its a case of grin and bare it. That same evening I found the back of my thighs and my scalp to be very itchy. As I've said above, it did have a few bumps on the back of my thighs, which felt more like pimples than anything else and didn't really bother me until then. 

Monday Jan. 19th, and I woke up feeling horrible, I had symptoms of a sore throat, runny nose, feeling cold and headaches at night. These symptoms persisted as the week went on and due to my next injection due on Thursday it was decided I would give it a miss. It should be noted that if you do feel sick while on a biologic and are due to take it around that time, it is best to not take it, as you could become more ill. My throat had worsened by Thursday and I felt congested in my nose.

I was sure to keep track of my symptoms and injections in my Enbrel diary. I also kept track of my psoriasis, which by Saturday 24th had worsened. It was now showing on my scalp, legs, back, stomach and my face. I was also still very congested at this stage. The following week I had noticed red patches on my thighs where I had injected. I contacted my nurse who had said to keep an eye on them. They were slightly red and a small bit raised but I was told nothing to worry about. It was now Thursday the 29th and as I was still sick, I was missing another injection, making it two weeks in a row without Enbrel. 

Monday Feb. 2nd which was a visit to my Rheumatologist who had prescribed Enbrel, for a month review. While in the last month, my joints had felt great, my skin was going the opposite way. He thought maybe the dosage was too much to start on so halved my dose to 25mg every week and to take a low dose of Methotrexate to help make it more effective.

I started my new routine of 25mg of Enbrel the following Monday, the 9th. The nurse had made the visit to help show me how to inject with a pre-filled syringe which is how 25mg comes. She got to see how back my skin had become and had supported my decision to go back to my dermatologist about my worsening skin and the possibility of starting phototherapy again. I took 10mg of MTX the same day, which was followed by 10mg of folic acid two days later.

I did find it strange injected with a syringe, but I managed to do so the second week with no supervision. I managed to get an appointment with my Dermatologist Feb. 17th and he looked over my skin and agreed with my thoughts on light treatment and I signed the appropriate forms and was book in for Feb. 23rd. I had 3 doses of 25mg of Enbrel in total before I was back to my rheumatologist for another review, and it was decided Enbrel was not beneficial to me and so it was stopped.

I was very unfortunate that Enbrel did more harm than good for me as I have heard and seen stories of how it has helped others with psoriasis and/or psoriatic arthritis. My Psoriasis had gotten so bad over my entire body, especially on my face which at times I felt I had to cover with makeup to avoid stares which were quite hurtful. I went on to continue phototherapy until May 8th 2015. I found it to be an expensive year as phototherapy 3 times a week at €30 a time which may not have been necessary had I not been prescribed Enbrel. Add in he cost of doctors visits on top of that and the fact I wasn't working. It probably seems like i'm cursing Enbrel and in a way, it was a negative experience but it did prepare me in other ways, such as injecting as I believe the nurse service is not available with some biologics.

As I always say, what happens to one might not happen to another and I know people whose lives have been made better by Enbrel. Its just a case of finding what works individually.

Did you have a similar experience? or what do you find works for you? let me know below.

Until next time....

Sarah x

My experience with Methotrexate

Welcome back again to the second installment of this series, this time about my experience with Methotrexate...

In 2006, the same year I had gone through the tonsillectomy, I had noticed my right knee was very swollen to the point that it was double the size of my left knee. When I had a check up with my dermatologist I had asked about my knee, he then informed me that Psoriatic arthritis is a possibility due to having Psoriasis and he refered me to a rheumatologist to look into it further.

I believe it was around September of the same year that I first saw another new doctor. He checked out my knee and said it was fluid after building up which is why is was that size. He then drained the fluid and showed me it in a cup. It was yellowish in colour 'like Heineken' my doctor proclaimed. I was also given any anti-inflammatory injection in my knee in the hope it would keep it calm.

I saw my doctor every few months and had fluid drained a few times, thankfully not to the extent of my first visit. He gave me a leaflet about Methotrexate (MTX) a tablet (also available in injection form nowadays) which was known to be good for types of Arthritis. I came to the decision I would try it in the hope it would help. I was then sent for a chest X-ray which has to be done upon starting MTX, as well as regular blood tests to keep a check on liver functions, as it can have an effect on the liver. I started on a low dose of 5mg, followed by folic acid two days later. The dosage was increased as the weeks went on, to 15mg, if I remember correctly. MTX can be disruptive to the stomach and I did experience a few stomach aches but it was worth it to help my knees.

I was still on MTX up until Decemeber 2014. Over the years I have had the dosage switched up and down, depending on how bad/ or well behaved my knees were. The highest I was on was 25mg, which did not agree with me back in December and ultimately was the final straw in changing to a biologic which my rheumatologist had always offered as an alternative.

Another reason for going off MTX was due to developing psoriatic arthritis in my left knee and also last year, in my right elbow. I visited my doctor every two to three months and was usually given a steroid injection to help with any inflammation which may have been happening at the time.

I found that MTX was effective for a while, as I was on it long enough but I just found as the years went on I needed to try something different. I think it is a good option to start off on if you are new to psoriatic arthritis and are unsure of the biologics which are usually injections. I have heard other peoples experience with this drug that they could not that it as it would make them feel so ill. Also it is not recommended to drink alcohol while on it due to the possibility of it having an affect on liver function, which is another thing that turns people off. As stated above, it is now available in injection form, something that wasn't an option when I started and I have heard some people say they prefer this method. 

Its all down to personal preference and we need to remember that even if one thing doesn't work for you but works for someone else, there are plenty of options out there. That is something that will ring through when I talk about Enbrel.

Again, any questions you might have about MTX, don't hesitate to ask.

Until next time....

Sarah x

My experience with.....

So this past Monday I returned from a week in the sun in Mallorca and I think I am only now readjusting back into normal life again. The weather was beautiful and my skin cleared up nicely as I wore shorts most days, and thankfully made sure I didn't get burned (check out my previous post for some tips). Unfortunately the last few days of being back, my skin has been starting to feel grainy again *fingers crossed* the sun shows itself here in Ireland a bit more.

Anyway I've come up with some fresh ideas with the blog, as you probably can guess from the title 'My experience with....' Is a going to be a series about the different types of treatment I have used from the time I first developed Psoriasis and Psoriatic arthritis, listed below;

- Topical creams/ointments
- Tonsillectomy
- Methotrexate
- Phototherapy (light treatment)
- Enbrel
- Cimzia
- Stelara (current treatment)

I've already written in detail about phototherapy, two of the three different times I did go through it so it is one topic I will touch on briefly over the series. As always, if I don't add something about any treatment that you do wish to know about, don't hesitate to ask, either in the comments below or privately.

I'll be starting through the above list in the next day or two, so keep your eyes peeled for that. I'll also post other bits In-between, any ideas again, do let me know :)

Until next time.....

Sarah x